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Initially characterized as the second incretin hormone [51], GLP-1 was later found to have pleiotropic action well outside the pancreas, with broad action in the brain and the periphery and which includes decrease of gastric emptying, inhibition of food intake, increase of natriuresis and diuresis, modulation of rodent -cell proliferation, decrease of inflammation and apoptosis, improvement of cardiovascular function, and modulation of learning and reward behavior [52] (Fig

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Putting It All Together: A Practical GLP-1 Optimization Plan Implementing all five strategies simultaneously may feel overwhelming

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