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The resulting oxidative overload disrupts redox-sensitive pathways (e.g., NF-B, Nrf2), promoting inflammation, fibrosis, and cellular apoptosis (Fountoulakis et al., 2025)

doi: 10.3389/fimmu.2023.1257422

199 Iron status was also improved in stage 3a CKD patients treated for nearly four months with mixtures of Bifidobacterium and Lactobacillus species in a randomized placebo-controlled trial with 28 participants

Based on these results, Weill Cornell Medicine is currently conducting a Phase II clinical trial to examine the effects of intravenous high dose vitamin C in the treatment of KRAS-mutant cancers, and Sun Yat-sen University Cancer Center in China are conducting placebo-controlled, randomized Phase III clinical trials in colorectal cancer patients in combination of chemotherapy