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Abbreviations AAA: Abdominal aortic aneurysms AT-I: Angiotensin-I BP: Blood pressure COX-1: Cyclooxygenase-1 COX-2: Cyclooxygenase-2 CT: Computed tomography DBP: Diastolic blood pressure ECG: Electrocardiogram eNOS: Endothelial nitric oxide synthase GFR: Glomerular filtration rate HTN: Hypertension iNOS: Inducible nitric oxide synthase LVH: Left ventricular hypertrophy LVM: Left ventricular mass MR: Magnetic resonance NMMA: N-monomethyl-L-arginine NOS: Nitric oxide synthase NSAIDs: Non-steroidal anti-inflammatory drugs PGH-2: Prostaglandin H2 RAAS: Reninangiotensinaldosterone system ROS: Reactive oxygen species RPE: Borg Rating of Perceived Exertion SBP: Systolic blood pressure UK: United Kingdom US: United states WHO: World health organization AMP: Adenosine monophosphate ANP: Atrial natriuretic peptide BNP: Brain or B-type natriuretic peptide CNP: C-type natriuretic peptide ET: Endothelin HMW: High-molecular-weight NO: Nitric oxide PPAR: Peroxisome proliferatoractivated receptor gamma mRNA: Messenger ribonucleic acid ACE: Angiotensin-converting enzyme AVP: Argininevasopressin DOCA: Deoxycorticosterone acetate SHR: Shared health records GRK: G protein receptor kinase DH: Dopamine -hydroxylase MR: Mineralocorticoid receptor CVD: Cardiovascular disease CYP: Cytochrome P450 HF: Heart failure MRA: Mineralocorticoid receptor antagonist DNA: Deoxyribonucleic acid ARTS: Mineralocorticoid Receptor Antagonist Tolerability Study RAS: Renin-angiotensin-system ARBs: Angiotensin receptor blockers HPCD: 2-Hydroxypropyl--cyclodextrin APA: Aminopeptidase A DH: Dopamine -hydroxylase HDL: High-density lipoprotein HFpEF: Heart failure with preserved ejection fraction HFrEF: Heart failure with reduced ejection fraction HOPE: Heart Outcomes Prevention Evaluation IDNT: Irbesartan Diabetic Nephropathy Trial LDL: Low-density lipoprotein NHE: Na + /H + exchangers NPR-A: Natriuretic peptide receptor A NPR-C: Natriuretic peptide clearance receptor s-EH: Soluble epoxide hydrolase UKPDS: UK Prospective Diabetes Study VIP: Vasoactive intestinal peptide VPAC1: Vasoactive Intestinal Peptide Receptor 1 VPAC2: Vasoactive Intestinal Peptide Receptor 2 WKY: Wistar Kyoto MAS: Mitochondrial assembly PL-3994: Novel natriuretic peptide receptor-A (NPR-A) agonist (HP--CD/Ang1-7): Hydroxypropyl--cyclodextrin incorporated Ang(17) formulation AVE0991: A nonpeptide angiotensin-(17) mimic CGEN-856S: A potential Mas agonist BIA 5453: A novel dopamine -hydroxylase (DH) inhibitor PB1046: A first-in-class vasoactive intestinal peptide (VIP) receptor agonist SLC9A3: Na( +)/H( +) exchanger isoform 3 LCI699: Osilodrostat FAD286: Aldosterone synthase inhibitor BAY 94-8862: Nonsteroidal mineralocorticoid receptor antagonist AR9281: Selective inhibitor of soluble epoxide hydrolase (s-EH) C-ANP4-23: Synthetic ligand that activates the natriuretic peptide receptor-C RB150: Prodrug of the specific and selective APA inhibitor EC33 EC33: Active molecule that inhibits the enzyme aminopeptidase A QGC001: Brain aminopeptidase A inhibitor LCZ696: A potential drug that suppress apoptosis, inhibit inflammation, and regulate the PI3K/AKT signaling pathway

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