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And because these compounds work through the pituitary rather than bypassing it, any pre-existing pituitary pathology needs clinical evaluation before starting

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Unlike GLP-1 agonists, DPP-4 inhibitors do not affect satiety, gastric emptying, or induce weight loss

Possible effects on energy balance and body composition: Some data suggest modest improvements in energy expenditure and preferential loss of fat mass versus lean mass, but appetite suppression is the dominant driver of weight loss