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Expected Results Timeline Understanding realistic timelines prevents frustration and premature protocol abandonment

Jamalpoor A, van Gelder CA, Yousef Yengej FA, Zaal EA, Berlingerio SP, Veys KR, Pou Casellas C, Voskuil K, Essa K, Ammerlaan CM, Rega LR, van der Welle RE, Lilien MR, Rookmaaker MB, Clevers H, Klumperman J, Levtchenko E, Berkers CR, Verhaar MC, Altelaar M, Masereeuw R, Janssen MJ (2021) Cysteamine-bicalutamide combination therapy corrects proximal tubule phenotype in cystinosis

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After IM injections of 20, 100, and 500 g/kg of BPC157 in rats and 6, 30, and 150 g/kg of BPC157 in beagles, plasma BPC157 reached its peak rapidly (within 9 min)