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However, with GLP-1 use growing in the U.S., Lemas said it is crucial to examine how GLP-1 exposure before pregnancy affects health outcomes for mothers and their offspring, especially as nearly half of pregnancies in the U.S

were unable to reproduce the positive lifespan data with the 0.1% metformin protocol in mice, although in combination with rapamycin (14 ppm) lifespan was extended (77)