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First, ROS directly modifies ion channels, oxidizing sulfhydryl groups on voltage-gated Na+ channels, resulting in abnormal action potential propagation and contributing to the paradoxical coexistence of pain and numbness (Elafros et al., 2022)

Tryptophan is one of the essential amino acids in the human body and is decomposed mainly through the kynurenine pathway, in addition to producing physiologically active substances, such as 5-hydroxytryptamine and melatonin

Berberine is hepatically metabolized, and impaired liver function alters berberine clearance and potentially its inhibition of CYP450 enzymes

More than one-third of those receiving semaglutide lost more than 20% of their weight