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Thai J Pharm Sci 39:127140 Cabrera CG, Goldberg DW, Nudelman NS (2005) Kinetic and mechanistic studies on the hydrolysis and photodegradation of diazepam and alprazolam

Metformin has been shown to cross the blood-brain barrier and its concentrations in the hypothalamus match those in plasma in rat experiments, and substantially metformin levels in the pituitary gland increase as well [95]