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In all cell types examined (p53-/-, p53+/- and p53+/+, p53 515A/+, and p53 515A/515A), DNA synthesis declined over the first 6 days in culture, though the mutant p53 lines always had higher synthesis rates than p53-/-, p53+/- and p53+/+ cells

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It extends its effect by maintaining GH secretion over longer periods, including preserving the natural episodic or pulsatile pattern of GH release rather than creating flat, constant levels

Consequently, IGF-1 LR3 has improved biological potency and extended half-life