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11,12 The risk of complications in SUSTAIN-6 was highest among patients with pre-existing diabetic retinopathy and rapid HbA1c reduction, suggesting that the findings reflect the early worsening of diabetic retinopathy that can occur with any method of lowering glucose, rather than direct retinal toxicity from GLP-1 RAs

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In adrenergic neurons containing dopamine- -hydroxylase, dopamine can be further hydrolyzed to generate norepinephrine (Hoffman et al., 1998)