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Surprisingly, these phenotypic consequences of CBP/p300 inhibition did not result in viability defects in NRF2-dependent cell lines

10.1038/nature17623 9 ArastehS.KhanjaniS.GolshahiH.MobiniS.JahedM

The most consistent finding: researchers who dose MOTS-c in the morning during fasted states report more pronounced shifts in substrate utilizationmeasured via respiratory exchange ratio (RER)than those administering it post-meal