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Study 5: Phase 2b clinical study, failure in obesity Citation: Metabolic Pharmaceuticals Phase 2b trial (2007), not fully published

29 At the cellular level, metformin was thought to primarily act on the mitochondrion and has an ephemeral inhibitory action on the complex I of the electron transport chain of mitochondria culminating to a dip in the energy level of the cell

this result indicates that the combination of chemotherapy drugs with ferroptosis inducers may be used to overcome drug resistance [303]

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