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Here are the three main reasons: GLP-1s Help With Conditions That Disproportionately Affect Bipolar Disorder Theres a high percentage of people living with bipolar disorder who also experience metabolic changes in their body that put them at risk for things like heart disease and type 2 diabetes, says Vijay Gorrepati, MD, psychiatrist at UT Health Austins Bipolar Disorder Center in Texas, which is associated with Dell Medical School