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Recognized as a key biomarker for sensitivity to ferroptosis induction, NADPH functions as a reductase for GSH, ensuring that GSH remains in its reduced, active state [55]

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As a matter of fact, taking into full account the intricacy of the numerous regulatory mechanisms involved in OS control as well as the complex interplay between the many events that contribute to the progressive degeneration and death of MNs, future neuroprotective pharmacological therapies will likely need to aim for an integrated treatment, acting on several levels to limit the progression of the disease