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GSH is regulated by GSH synthase, GSH peroxidase and GSH reductase (GR).9 GR, which is one of the key enzymes in the redox system of the human body, is ubiquitous in the liver, kidney, heart, erythrocytes and other tissue cells, and it primarily functions to convert oxidised GSH (GSSG) into reduced GSH, scavenge oxygen free radicals and protect cells from oxidative damage

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Vagotomy in animal studies is said to disrupt the transfer of -synuclein derived from the gut to the CNS, but human observational evidence is inconsistent, with some studies indicating no change in PD incidence and others suggesting a reduced risk following truncal vagotomy (Elfil et al., 2020)