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Incretin-based therapy of metabolic disease Abstract Incretin-based therapy of metabolic disease Recent studies show that incretin hormone analogues effectively control blood glucose while producing major weight losses and reducing the risk of all-cause mortality, myocardial infarction, stroke and kidney function impairment

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Based on Phase 2 clinical trial data published in the New England Journal of Medicine (Jastreboff et al., NEJM 2023

Conversion of biliverdin to bilirubin by biliverdin reductase contributes to endothelial cell protection by heme oxygenase-1-evidence for direct and indirect antioxidant actions of bilirubin