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First oral semaglutide made a strong impression in OASIS-1 #obesity with 15% #weightloss now orforglipron leads the impressive pack of new small molecule oral GLP-1RA with robust #Weightloss and good tolerability ADA2023 First oral semaglutide made a strong impression in OASIS-1 #obesity with 15% #weightloss now orforglipron leads the impressive pack of new small molecule oral GLP-1RA with robust #Weightloss and good tolerability ADA2023 The receptor ligand binding, biased signaling, and preclinical pharmacology of the oral small molecule GLP-1RA orfoglipron was described in 2020 by @chugai_cc @LillyDiabetes in @PNASNews #T2D #obesity pnas.org/doi/10.1073/pn Whats the definition for good tolerability?

This naming confusion isn't just about words

Pass the celery sticks." But hold your horses

[3] The practical result of that research is a molecule that behaves very differently from native IGF-1 in laboratory systems, and that has since become a widely stocked reagent for cell-culture applications