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In addition, chronological aging of the skin is influenced by genetics, metabolism, and hormonal, immunological, cardiovascular, gastrointestinal, psychogenic (involving stress or affective disorders), degenerative, or neoplastic disease [16,17,18]

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SUMMIT Trial Study Group, Packer M, Zile MR, Kramer CM, Baum SJ, Litwin SE, Menon V et al (2025) Tirzepatide for heart failure with preserved ejection fraction and obesity