The Dysaesthesia Gap (7.2mg): A more recently emerging adverse event, high-dose semaglutide is hitting great numbers (-18.3% net weight-loss), but a 22.9% rate of dysaesthesia suggests the drug is hitting the CNS in a way that causes discomfort
Your doctor will typically: Check blood tests (potassium, kidney function) before starting and periodically during treatment Monitor your blood pressure regularly Adjust either medications dose based on your response and any side effects Possibly increase monitoring frequency if you have heart failure, kidney disease, or take other medications affecting potassium Take home message Mounjaro and spironolactone can be taken together safely, but this combination requires appropriate monitoring of potassium levels, kidney function, and blood pressure
These qualifications include being an adult with a body mass index (BMI) that is equal to or greater than 30 mg/kg2, or those who have a BMI of 27 mg/kg2 and also have at least one professionally diagnosed weight-related condition such as high blood pressure or high cholesterol
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