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Alpha-lipoic acid is another antioxidant sometimes recommended for liver support, and whilst it can help regenerate glutathione, taking both in high doses may be redundant for some people

Experimental autoimmune thyroiditis (EAT) models have demonstrated that pharmacological blockade of S1P signaling ameliorates thyroid inflammation and reduces TSH levels, underscoring a bidirectional crosstalk between thyroid dysfunction and liver inflammation via ECM pathways (93)

The latter effects are demonstrated by relatively greater increase in IGF-1 after 30-d stimulation with GHRP-2