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Notably, depletion of microglia using the CSF1R antagonist PLX5622 attenuated stress-related transcriptional changes not only in microglia but also in leukocytes, endothelial cells, and astrocytes, underscoring the central role of microglia in orchestrating stress responses across multiple cell types

Nausea typically occurs during the first 4-8 weeks of treatment or following dose increases, with many patients experiencing gradual improvement as their body adjusts to the medication

In addition to the ominous octet, further pathways contributing to hyperglycemia have been delineated, which include systemic low-grade inflammation [6, 7], changes in gut microbiota [8, 9], and reductions in amylin production [10]

Homocysteine levels lower than 7 mol/L in adults can indicate that there is not enough homocysteine for normal glutathione production