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Funding This work was supported by the Henan Provincial Breast Cancer Precision Prevention and Control Engineering Research Center (ZC20220050), the Henan Provincial Peoples Hospital23456 Talent Engineering Project (ZC23456026) and the study on the Effect and Mechanism of Macrophage-Derived Exosomes Loaded with Doxorubicin for Targeted Therapy of Triple-Negative Breast Cancer (ZC20220114)

Some of the detected disproportionate signals of adverse reactions overlapped somewhat with the clinical manifestations of the therapeutic drug indications, which prevented our study from distinguishing between them

These conflicting results may be explained by the shorter treatment received in the EMPACEF study (12 weeks) [104], compared to the 6 months used in the EMPA-TROPISM study [32]

Mkel R, Leinonen A, Suominen T