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It refers to the 15-amino-acid chain that defines this synthetic peptide, the same sequence first identified in human gastric juice and studied in research contexts for decades

At 52 weeks, the semaglutide group showed a statistically significant reduction in areal bone mineral density at the total hip (estimated treatment difference: -0.020 g/cm, p = 0.001, equating to approximately 2.6% loss) and at the lumbar spine (ETD: -0.018 g/cm, p = 0.007, approximately 2.1% loss)

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