Integrating UGT inhibition data into the rule-of-two model significantly enhances the prediction accuracy for drug-induced liver injury (DILI) (119)
Chemical properties Chemical Name: L--glutamyl-L-cysteinyl-glycine Molecular Formula: C10H17N3O6S CAS: 70-18-8 (reduced form) Molecular Weight: 307.32 g/mol Biological Significance Antioxidant Protection In our daily lives, the body constantly produces reactive oxygen species (ROS) and free radicals, which attack cell membranes, proteins, and DNA, causing oxidative stress, accelerating aging, or triggering diseases
Rarely, rashes or skin reactions have been reported
Abbreviations ALT Alanine aminotransferase AST Aspartate aminotransferase BMI Body mass index CAP Controlled attenuation parameter FBS Fasting blood sugar HbA1c hemoglobin A1c HDL High-density lipoprotein IRI Immunoreactive insulin LDL Low-density lipoprotein LSM Liver stiffness measurement NAFLD Nonalcoholic fatty liver disease NASH Nonalcoholic steatohepatitis NEFA Non-esterified fatty acid UMIN University Hospital Medical Information Network VCTE Vibration-controlled transient elastography Authors contributions Designed and coordinated the study: TK, YH, YS, and AN
