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Administrated resveratrol positively affects the synthesis of sirtuins, SIRT1 (a family of proteins NAD + -dependent histone deacetylases playing an important role in the regulation of metabolic pathways, see below) activating then superoxide dismutase 2 (Mn-SOD) expression in cardiomyocytes and improved cardiac functions (Tanno et al

[DOI] [PubMed] [Google Scholar] 64.Wang J., Lai S., Zhou T., Xia Z., Li W., Sha W., Liu J., Chen Y

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Inflammatory responses were also suppressed by SCH23390 in a SCID-mouse model of murine RA, while D2-like receptor suppression with haloperidol increased the accumulation of IL-6 + and IL-17 + T-cells (Nakano et al., 2011)