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While it is intuitively assumed that antioxidants emerged during the GOE to defend against O 2 reactivity and toxicity caused by the accelerated oxygenation of the atmosphere, sequencing and phylogenetic analyses of antioxidant systems from ancient organisms suggests that antioxidant enzymes including SODs may have originated long before the surge of atmospheric and oceanic O 2 (Wolfe-Simon et al

It is the only biologically active form in humans

They found that riluzole increased the proportion of GABA relative to the other chemicals in adults with autism and lowered it, albeit only slightly, in controls

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