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Unexplained increases in blood glucose readings, return of diabetes symptoms (increased thirst, frequent urination, fatigue), or sudden changes in appetite and weight loss patterns may suggest reduced medication potency

The FDA-approved dosing schedule includes a gradual titration strategy specifically designed to minimize gastrointestinal side effects, starting at 2.5 mg weekly and increasing every four weeks as tolerated

The problem is cumulative

Many patients do switch between medications under the supervision of a healthcare provider, especially if they have hit a weight loss plateau or are looking for better results