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Despite recent advancements in therapeutic options, it is still one of the most clinically challenging blood cancers, with a notably low 5-year survival rate of 30% and a high rate of relapse 1,2

[PMC free article: PMC5117680] [PubMed: 27842768] (Review of the frequency, clinical features, patterns of injury and outcomes of HDS hepatotoxicity with specific mention of anabolic steroids, black cohosh, germander, green tea, kava, pyrrolizidine alkaloids and proprietary multiingredient nutrition supplements [MINS])

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For example, selonsertib (GS-4997) is a highly selective and potent ASK1 inhibitor with potential anti-inflammatory, anti-tumour, and anti-fibrotic activities 40