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Vallhonrat et al

Similarly, in MDD patients treated with SSRIs, 8-week treatment increased the KYNA/3-HK ratio and showed early increases in KYN/TRP at week 4 among responders [194]

While its ability to influence multiple pathways of repair is supported by compelling preclinical data, the absence of high-quality human trials, the FDAs strict regulatory stance, and the risk of contamination from unregulated sources raise serious safety and legal concerns (including malpractice concerns and fines)

Most of the studies have shown its therapeutic role in melasma, whereas some studies have contradicted this fact[] [Table 1]