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From a development chemists perspective, Melanotan II is the more pharmacologically noisy molecule: it delivers more signal per milligram, but much of that signal is not targeted at tanning alone, elevating the risk of off-target or unanticipated effects

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Both studies demonstrated that FSP1 acts as an NADH/NADPH-dependent CoQ 10 reductase that predominantly localizes to the plasma membrane via N-terminal myristoylationa posttranslational modification essential for its antiferroptotic activity