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Translational, immunocompatibility, and regulatory considerations Despite the rapid progress in smart hybrid nanomaterials for chronic infections, their successful clinical translation remains a considerable challenge

The functions of the CysLTs are mediated via two known G protein-coupled receptors: the CysLT type 1 receptor (CysLT1R) and the CysLT type 2 receptor (CysLT2R) [17,18,19]

Carl Zeiss AG)

It remains uncertain whether distinct initiation mechanisms trigger the inflammatory response by acting on priming signaling pathways, or if a reduction in the negative regulation of NLRP3 activation amplifies the inflammatory cascade