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GLP-1/GIP/GLUCAGON is a synthetic peptide that functions as a triple receptor agonist, targeting GLP-1 (glucagon-like peptide-1), GIP (glucose-dependent insulinotropic polypeptide), and glucagon receptors

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Other mechanisms on which Metformin play an action are: mammalian target of rapamycin (mTOR, crucial to tumor cell metabolism), adenosine mono-phosphate-activated protein kinase (AMPK), mitochondrial glycerophosphate dehydrogenase (mGPDH), and the nuclear factor kB (NF-kB) (Kushchayeva et al., 2014

38 Platelets in PRP also contain inflammatory mediators and modulators