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The first generation of GLP-1 therapies exhibit reduced susceptibility to enzymatic degradation, while providing effective glucose control, improved -cell function, body weight loss and decreased systolic blood pressure in patients with T2D (Meier, 2012) The newly developed incretin mimetics, including albiglutide, dulaglutide and semaglutide, are designed to have extended pharmacokinetic profiles and efficacy suitable once-weekly administration

The phenomenon of oxidative stress originates from the imbalance between intracellular oxidants and antioxidant systems, and this biochemical process is essential to the pathological mechanism of PCOS

El mecanismo de accin incluye varios efectos fisiolgicos importantes: estimulan la secrecin de insulina cuando los niveles de glucosa estn elevados, suprimen la liberacin de glucagn (hormona que aumenta el azcar en sangre), retrasan el vaciamiento gstrico y actan sobre centros cerebrales que regulan el apetito y la saciedad

Functionally no GLOW is a multi-mechanism research tool engaging three complementary pathways