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GLP-1 plays an immunomodulatory role

This has been confirmed in meta-analyses of tens of clinical trials concerning statins published in the last few years which demonstrated a significant reduction in Alzheimers dementia, vascular dementia, and generally mild cognitive impairment with statin use [376, 377], of which pleiotropic properties of this class of agents are supposed to be the cause

As commercial supply stabilizes, the clinical justification for compounding these agents narrows

Moreover, mechanistic studies offer promising pathways, such as neurotrophin signaling, oxidative stress modulation, and inflammatory regulation, but are still primarily grounded in animal models