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Secondly, this systemic inflammatory state activates local hepatic immune cells, including Kupffer cells, neutrophils, and dendritic cells, promoting the activation of signaling pathways such as NF-B and the NLRP3 inflammasome, which in turn induce hepatocyte injury and amplify inflammatory responses

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In intention-to-treat analyses, semaglutide 7.2 mg still delivered impressive results with 18.7% average weight loss versus 15.6% for the 2.4 mg dose and 3.9% for placebo