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The aim of surgery for IVD disease is to relieve the compression of neural structures, and procedures include removal of the NP (nucleotomy) through fenestration of the AF alone or combined with partial removal of the vertebral roof (laminectomy) or vertebral body (ventral decompression) [12]

In light of all these studies, it should be emphasized that blood glucose should be monitored regularly when initiating or adjusting antidepressant therapy, and patients with diabetes should also be monitored for depressive symptoms due to the bidirectional relationship

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The ability of these compounds to influence metabolic pathways underscores the importance of dosage and timing in achieving beneficial effects while minimizing potential toxicity