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2.2.5 Interplay with the TME and trafficking Tumor environmental cues feed back on RNA-modification circuits

The products covered by the expanded CLAA framework include CAR-T cell therapies, gene editing and gene replacement treatments, and animal tissue-derived products such as heart valves

According to the literature, the prevalence of depression is significantly higher in patients with type 2 diabetes than in those without diabetes (17.6% vs

When to contact your GP or diabetes specialist nurse: If you've been taking expired Rybelsus and notice worsening blood glucose control If you experience unexplained symptoms such as persistent thirst, increased urination, or fatigue If you're unable to obtain a fresh supply of your medication For advice on alternative diabetes management strategies if Rybelsus is temporarily unavailable Seek urgent medical advice (call NHS 111) or emergency care (999) if you experience: Severe dehydration (extreme thirst, dry mouth, little or no urination) Confusion or drowsiness Rapid breathing Severe abdominal pain or persistent vomiting Very high blood glucose levels that don't respond to usual treatment These could be signs of severe hyperglycaemia or hyperosmolar hyperglycaemic state (HHS), which requires immediate medical attention