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presence of hypoglycemia unawareness
1 As per stability technical specification data, when the patient is ready to inject, it typically takes an average of 3-4 seconds a month to administer
Preclinical work has shown that cagrilintides weight-lowering effects are mediated primarily via AMY1 and AMY3 receptor subtypes, which are highly expressed in appetite-regulating regions of the brain
In line with this hypothesis, an observational study of 200 adults with type 1 diabetes demonstrated improvements in albuminuria and in eGFR with SGLT2i use over 12 months among adults with a baseline eGFR 7000 participants identified a 2.8-fold greater risk of DKA with SGLT2i use compared with placebo in adults with type 1 diabetes [44]
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