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We found that the long-lived glp-1(-) and fem-3(-) mutants employ a similar lifespan extension mechanism converging on the transcription factor DAF-16/FOXO, which is partially stimulated by excess lipid

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On the other hand, expression levels of hepatic Cpt1a, Ppara, Hmcs2 and Fgf21 , and circulating ketone bodies and FGF21 found highly elevated at 72 h in G49-treated mice are indicative of the contribution of FFA catabolism and ketogenesis to the lipid clearance

The most common setup is a 10 mg retatrutide vial + 2 mL BAC water = 5 mg/mL