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Confirmed in the 2004 Phase 2 trial where fasting glucose remained unchanged after 12 weeks of daily dosing

Dexamethasone (DEX) administration markedly increased Keap1 expression (1.60 0.10) compared to the control group (1.00 0.04), indicating suppression of the Nrf2 pathway

The weight loss achieved by CagriSema (-20.4% at 68 weeks) is comparable to that reported with the dual glucose-dependent insulinotropic polypeptide (GIP)/GLP-1 receptor agonist tirzepatide (-20.9% with the 15-mg dose at 72 weeks in SURMOUNT-1) [14]

Reduced glutathione (GSH) is a tripeptide molecule garnering interest in health and wellness circles due to its powerful roles in antioxidant defense, detoxification, and cellular repair