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FIGURE 1 GLP-1 also plays an important role in activating the glucose sensor in the portal vein ( Because interaction of GLP-1 with receptors in the intestine is sufficient to activate all major responses required to impact both diabetes and obesity, it is anticipated that the administration of GLP-1 receptor agonist (GLP-1 RA) in such a way that they pass across intestinal tissue, should be an ideal method for delivering these peptides

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This is partly because the levels in your body fluctuate