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It would also help explain a clinical observation discussed later: the gastrointestinal side effects associated with amylin analogs (nausea, early fullness) tend to be most pronounced during dose escalation and to ease with continued treatment, a pattern consistent with partial adaptation of the very gastric mechanism in question

In a transcriptomic analysis of pre-menopausal and peri-menopausal stromal fibroblasts, over 1,000 genes were found to be differentially expressed between these two age groups (Erikson et al., 2017)

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The average body mass index when they enrolled in the study was 37 kg/m 2 , which is considered obesity