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Cross-tolerance to opioids refers to the property of tolerance that has developed following chronic exposure to one opioid that generalizes to a second opioid

As you can see, there are a variety of other approaches

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512 Deficits of astrocytic support of synaptogenesis can also be linked to a decrease in secretion of astrocyte-specific synaptogenic molecules such as hevin, SPARC proteins and thrombospondin-1