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Aerobic bacteria and fungi use an O 2 -dependent reaction that is catalyzed by a mononuclear non-heme iron enzyme, with cysteine or -glutamylcysteine as the sulfur source
The structure reveals that the side-chain of the -tyrosine amino acid residue is situated in the S1 pocket of the enzyme and that the disulfide bond abuts to the S1 pocket
The malabsorptive environment of IBD often leads to deficiencies in these microbially-synthesized vitamins, contributing to cognitive slowing and mood dysregulation (Wang et al., 2025)
doi: 10.1002/mnfr.202300734 105 CarvalhoFAKorenOGoodrichJKJohanssonMENalbantogluIAitkenJDet al
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