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Glucagon also contributes to energy homeostasis by promoting satiety through vagal signaling to brainstem nuclei and by increasing resting energy expenditure through facultative thermogenesis in brown adipose tissue, skeletal muscle, and through promotion of WAT browning [22]

In addition, the transcription factor SRY-box transcription factor 2 (SOX2) has been shown to interact with Shh and regulate progenitor differentiation [67]

It belongs to a class of drugs known as GLP-1 receptor agonists, which help regulate blood glucose levels by enhancing insulin secretion, slowing digestion, and reducing appetite

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