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There is currently no evidence that menopausal hormone therapy reduces the effectiveness of GLP-1 medications or that GLP-1 medications make hormone therapy unsafe

As the ABC noted in its reporting on the Victorian cases, the injectable medication has not been approved by any worldwide drug regulator. It is still moving through clinical trials, where it is one of the most effective compounds the obesity field has ever produced

Quick Verdict: The retatrutide + MOTS-c stack is considered one of the most promising metabolic research combinations in 2026

Daily protein targets matter with GLP-1s, with a recommended intake of roughly 60 to 75 grams per day, split across 3 to 4 meals, so each sitting delivers about 20 to 30 grams