pharma news today glp-1 Big is lying to you…, If you think medications actually work, think again…, Studies show when you stop taking them, you regain the weight back (PMID: 41500720)…, This isn’t surprising Novo cuts GLP-1 prices 70%,

One possibility is that changes in miR203-5p (and/or other miRNA molecules not examined in the present study) lead to transcriptional changes, potentially through other epigenetic mechanisms such as histone methylation/acetylation and heterochromatin modifications, that escalate over time and result in impaired glutamate homeostasis and glutamate-GABA communication

"ATTAINMAINTAIN showed that orforglipron, a once-daily oral GLP-1, helped people maintain the weight they worked hard to lose." This data provides the first robust, Phase 3 evidence that an oral "step-down" or "switch" strategy is not just feasible but effective, offering a new pathway for the long-term management of obesity

The highest dose of orforglipron helped patients lose on average 10.5% of their weight, or 22.9 pounds, on average at 72 weeks, compared to 2.2% weight loss among those who took a placebo

Raun et al