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Takeaway Message Glutathione may help to enhance brain health, improve insulin sensitivity, and reduce inflammation

Complement system can be directly activated by hepatocytes through antibody recognition, lack of membrane-bound regulators, and extracellular matrix proteins exposure (Nilsson et al., 2014), and indirectly by the crosstalk with coagulation system

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Hyperuricemia contributes to glucose intolerance of hepatic inflammatory macrophages and impairs the insulin signaling pathway via IRS2-proteasome degradation