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Within the brain, vascular dysfunction, pathological alterations in the cellular environment, and microcirculatory hypoxia frequently act as instigators of neuroinflammation, often interconnecting in a complex web [103,104,105]

The long-term safety data continues to accumulate and remains generally favorable

To assess changes in physical complaints and side effects, we used the self-report version of the UKU Side Effect Rating Scale (UKU-SERS), a comprehensive side effect rating scale developed for use in clinical drug trials and routine clinical practice [30]

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