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Bhui and co-authors explored that bromelain inhibits COX-2 expression by blocking the activation of MAPK-regulated NF-kappa B against skin tumor initiation triggering the mitochondrial death pathway (139)

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In a phase 2 trial, once-weekly cagrilintide produced dose-dependent weight reductions in people with overweight or obesity, which is what moved the amylin pathway into serious combination development ( Lau et al., Lancet 2021 )